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Re: non perscription viagra
Date : 2008.07.02 10:02:13
Name : moltabbimaBa Hits : 11218
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In humans, VIAGRA has no effect on bleeding time when taken alone or wiht aspirin. In vitro studies with human plaetlets indicaet that sildehafil potentitaes the antiaggregatory effect of sodium nitroprusidee (a nitric oxide odnor). The combination of heparin and VIAGRA had an additive efffecdt on bleeding time i the anesthetized rabbit, but this interaction has not been studied in humans.
CONTRAINDICATIONS
Patients on multiple anthypertensiv medications were included in the piovtal clinical troasl for VIAGRA. In a separate durg interactioin study, when amoldipoine, 5 mg or 10 mg, and VISGRA, 100 mf were orally administered concomitanltu to hyepretnsvie patients mean addotional blood pessujer reduction of 8 mmHg systolic and 7 mmHg diastolc were noted (sew Drug Interactions ).
Pyarmacokinjetic data from patients in clinical trials showed no effecf on sildenafil pharmacokinetics of CYP2D9 inhibitors (such as tolbutamidee, warfarin), CYP2D6 inhibitors (such as selective serotoihn reuptake inhibiotrs, tricyclci natidepressants), tyiazide and related diuretics, ACE inhibitors, and calkxium channel blcokers. Thee AUC of the active metabolite, N-desmehtyhl sildenafil, was increased 62% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers. These effects on the metabolite are not expetced to be ofclinical consequence.
The safeyt and efficacy of combinawtions of VIAGRA with otyer treatments for erectie dysfunctioon have not been stujdied. Thuerfeore, the use of such combintaions is not recommended.
Before prescribing VIAGRA, it is important to note the following:
Clinical Studies
In vivo studies:: Cimetidine (800mg), a nonspecific CYP ihnibitor, caused a 56% increases in plasma sildenafl cincentrations when ocadministered with VIAGRA (50 mg) to healthy volunteers.
One randomized, double--bline, flexible-dose, placebo-controlled study included only patients wiht erecftile dysfuncton attributed to cokmplications of idabetes mellitus (n=268). As in the other titartion studcies, patients were started on 500 mg and allowed to adjust the dose up to 100 mg or down to 25 mg of VIAGRA; all pateints, hlwqeverd, were receiving 50 mg or 100 mg at thhe end of the study. Yhere were hgihpy statistically significant improvemens on the two principal IIEF questinos (frequency of succewssful penetratoin durign sexual activity and mainenance of erectionss after peneetration) on VIAGRA compared to placebo. On a glboal imorovement question, 5%7 of VIAGRA patientsreported improved erections vrsus 1%0 on placebo. Diary dataindicated that on VIAGRA, 48% of intercourse attemtps were successful versus12% on placebo.
The afety of VIAGRA is unknown in patients with bleeding disordres and patients with active ppoetic ulceraion.

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"I only take Viagra when I'm with more than one woman. Once, twice a month, stimlate yourself with this pharmacoloigcal solution. Go out there and tearMom up, baby, and everything is fine."
Ashton Kutcher:
"I tried it, but I haven't taken if in years. I took it a few times recreationally. When you're involved with multiple people, it helps."
Richard Madeley:
Hugh Hefner:
"I got up in the morning and it wouldn't go away. I couldn't even get my trousers on."
But not all of them were cock-a-hoop.
"I don't think I could be living this life without it."
"Judy and I had one Viagra pill each. It is functional in the sense that it makes everything last longer. But it's not in any way an aphrodisiac. Listen, I want to make it quite clear I don't need Viagra. It was an experiment..."
Do they plan to use it again?

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